Reactome Pathway Analysis

2 Pathway Enrichment Analysis Enrichment analysis is a widely used approach to identify biological themes. Here, we implement hypergeometric model to assess whether the number of selected genes associated with reactome pathway is larger than expected. We also implement a category net model for viusalization. • Hypergeometric model Hypergeometric model was implemented to assess whether the number of selected genes associated with reactome pathway is larger than expected. • Category Net Plot Category-gene network model was implemented to extract the complex relationships between genes and pathways. It provides a high-level model to understand the functionalities of genes. • Case Study Here, we used a vector of sample entrezgene ID, which was converted from an example list of genes from ProfCom http://webclu.bio.wzw.tum.de/profcom/examples.php.